Cancer Cell 16 4 — Cancer Res 73 7 — J Clin Oncol 27 11 — Breast Cancer Res Treat 1 — Cancer Res 67 17 — Cancer Res 68 8 — J Intl Med Res 41 4 — Br J Cancer 10 — Biochem Biophys Res Commun 1 — Breast Cancer Res Treat 2 — J Transl Med Oncol Lett 6 5 — Immunity 22 3 — J Immunol 12 — Clin Breast Cancer 13 4 — Am J Transpl 4 7 — Article Google Scholar. Foxp3-positive macrophages display immunosuppressive properties and promote tumor growth J Exp Med 12 Blood 5 — J Immunol Methods 1—2 — Mol Ther 22 1 — Cancer Res 63 23 — Nat Rev Cancer 7 11 — Nat Immunol 8 3 — J Immunol 9 — Cancer Gene Ther 19 1 — Cancer Res 67 1 — Curr Opin Immunol 22 5 — Nat Med 19 9 — PLoS One 8 1 :e Annu Rev Immunol — J Cell Physiol 1 — Download references.
Christel Devaud, Phillip K. Don't show this again. Search Fields » Search result. Gene name. Class Biological process Molecular function Disease. External id. Reliability Enhanced Supported Approved Uncertain. Reliability Supported Approved.
Validation Supported Approved Uncertain. Annotation Intracellular and membrane Secreted - unknown location Secreted in brain Secreted in female reproductive system Secreted in male reproductive system Secreted in other tissues Secreted to blood Secreted to digestive system Secreted to extracellular matrix. Searches Enhanced Supported Approved Uncertain Intensity variation Spatial variation Cell cycle intensity correlation Cell cycle spatial correlation Cell cycle biologically Custom data cell cycle dependant Cell cycle dependent protein Cell cycle independent protein Cell cycle dependent transcript Cell cycle independent transcript Multilocalizing Localizing 1 Localizing 2 Localizing 3 Localizing 4 Localizing 5 Localizing 6 Main location Additional location.
Type Protein Rna. Phase G1 S G2 M. Cell type. Expression Not detected Low Medium High. Cell type Any Alveolar cells type 1 Alveolar cells type 2 B-cells Basal glandular cells Basal keratinocytes Bipolar cells Cardiomyocytes Cholangiocytes Ciliated cells Club cells Collecting duct cells Cone photoreceptor cells Cytotrophoblasts Distal tubular cells Ductal cells Early spermatids Endothelial cells Enterocytes Erythroid cells Exocrine glandular cells Extravillous trophoblasts Fibroblasts Glandular cells Granulocytes Hepatocytes Hofbauer cells Horizontal cells Intestinal endocrine cells Ito cells Kupffer cells Late spermatids Leydig cells Macrophages Melanocytes Monocytes Mucus-secreting cells Muller glia cells Pancreatic endocrine cells Paneth cells Peritubular cells Proximal tubular cells Rod photoreceptor cells Sertoli cells Smooth muscle cells Spermatocytes Spermatogonia Suprabasal keratinocytes Syncytiotrophoblasts T-cells Undifferentiated cells Urothelial cells.
Category Cell type enriched Group enriched Cell type enhanced Low cell type specificity Not detected Detected in all Detected in many Detected in some Detected in single Is highest expressed.
Category Cell line enriched Group enriched Cell line enhanced Low cell line specificity Not detected Detected in all Detected in many Detected in some Detected in single Is highest expressed. Category Lineage enriched Group enriched Lineage enhanced Low lineage specificity Not detected Detected in all Detected in many Detected in single Is highest expressed.
Prognosis Favorable Unfavorable. Antibodies Yes No. General description of the gene and the encoded protein s using information from HGNC and Ensembl , as well as predictions made by the Human Protein Atlas project. Full gene name according to HGNC. Official gene symbol, which is typically a short form of the gene name, according to HGNC.
The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more. Tissue enhanced blood, lymphoid tissue. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.
Cell type enhanced Horizontal cells, T-cells, Melanocytes, Alveolar cells type 2, granulocytes. Immune cell enriched T-reg. The regional specificity category is based on mRNA expression levels in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species.
The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Low human brain regional specificity.
Prognostic marker in cervical cancer favorable , head and neck cancer favorable and endometrial cancer favorable. All transcripts of all genes have been analyzed regarding the location s of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Development of a unique epigenetic signature during in vivo Th17 differentiation. Nucleic Acids Res. Izcue, A. Regulatory lymphocytes and intestinal inflammation. Huang, Y. Ayyoub, M. Beriou, G. ILproducing human peripheral regulatory T cells retain suppressive function. Blood , — Voo, K. Valmori, D.
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Brochet, X. Lefranc, M. Download references. You can also search for this author in PubMed Google Scholar. Correspondence to J Huehn or M Lochner. Reprints and Permissions. Yang, BH. Mucosal Immunol 9, — Download citation. Received : 19 February Accepted : 07 July Published : 26 August Issue Date : March Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative.
Mucosal Immunology Laboratory Investigation Nature Immunology Advanced search. Skip to main content Thank you for visiting nature. Download PDF. Abstract Foxp3 forkhead box P3 transcription factor -expressing regulatory T cells Tregs are essential for immunological tolerance, best illustrated by uncontrolled effector T-cell responses and autoimmunity upon loss of Foxp3 expression.
Figure 1. Full size image. Figure 2. Figure 3. Figure 4. Figure 5. Figure 6. Figure 7. References 1 Bilate, A. Article Google Scholar 32 Fisson, S. Article Google Scholar 34 Huehn, J. Article Google Scholar 37 Miyao, T. Article Google Scholar 58 Silver, J. Article Google Scholar 59 Bolstad, B. Article Google Scholar 61 Brochet, X. View author publications.
Ethics declarations Competing interests The authors declared no conflict of interest. Supplementary information. Supplemenatry Figures PDF kb. PowerPoint slides PowerPoint slide for Fig.
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